Canine Cyclic Neutroenia
( Gray Collie Syndrome)
Go to the HealthGene Site to learn more.
DESCRIPTION Canine Cyclic Neutropenia is a stem cell disorder that
occurs in collies. Puppies are usually smaller and weaker than their
litter mates and by 8 to 12 weeks of age they develop clinical signs such
as fever, diarrhea, joint pain, or other signs associated with eye,
respiratory, or skin infections. The disorder is caused by an abnormality
of the stem cells in the bone marrow, from which all blood cells are
developed. The result is a cyclic fluctuation in blood cell numbers. Every
10 to 12 days the number of neutrophils drops dramatically, and then
rebounds.
There is an increased susceptibility to infection corresponding to the dip
in neutrophil numbers. Affected dogs are subject to severe recurring
bacterial infections, primarily of the respiratory or gastrointestinal tract.
These dogs are also prone to bleeding episodes due to the drop in blood
cells numbers. This is a serious genetic disorder. Even with the best of
care, affected dogs rarely live beyond 2 or 3 years of age. Most die
within the first few weeks.
The disease occurs in all gray (not merle) collies. Affected puppies have
a silver gray hair coat that ranges in color from very light, to darkish
pewter gray, sometimes with a slight yellowing due to a mixture of light
beige and light gray hair. No matter what color variation or type, all
Collies have black noses EXCEPT those with gray collie syndrome. If the
nose continues to come in gray, then that is pathognomonic (absolutely
diagnostic) for "gray collie syndrome". Sable "gray collie syndrome" dogs
have brown or pale sable noses, but never black noses as they should
have.
DNA TEST
HealthGene Laboratory is the first DNA diagnostic laboratory that has
developed and offered a DNA-based test for Canine Cyclic Neutropenia.
HealthGene's test provides a reliable identification of dogs that carry
mutant gene(s). This test allows a breeder to control the mutant gene
frequency in the Collie breed thus preventing the production of puppies
affected with Canine Cyclic Neutropenia. This DNA test accurately and
specifically identifies normal, carriers (heterozygous) and affected dogs.
this test has been developed for the breeder so we can avoid this
disorder
( Gray Collie Syndrome)
Go to the HealthGene Site to learn more.
DESCRIPTION Canine Cyclic Neutropenia is a stem cell disorder that
occurs in collies. Puppies are usually smaller and weaker than their
litter mates and by 8 to 12 weeks of age they develop clinical signs such
as fever, diarrhea, joint pain, or other signs associated with eye,
respiratory, or skin infections. The disorder is caused by an abnormality
of the stem cells in the bone marrow, from which all blood cells are
developed. The result is a cyclic fluctuation in blood cell numbers. Every
10 to 12 days the number of neutrophils drops dramatically, and then
rebounds.
There is an increased susceptibility to infection corresponding to the dip
in neutrophil numbers. Affected dogs are subject to severe recurring
bacterial infections, primarily of the respiratory or gastrointestinal tract.
These dogs are also prone to bleeding episodes due to the drop in blood
cells numbers. This is a serious genetic disorder. Even with the best of
care, affected dogs rarely live beyond 2 or 3 years of age. Most die
within the first few weeks.
The disease occurs in all gray (not merle) collies. Affected puppies have
a silver gray hair coat that ranges in color from very light, to darkish
pewter gray, sometimes with a slight yellowing due to a mixture of light
beige and light gray hair. No matter what color variation or type, all
Collies have black noses EXCEPT those with gray collie syndrome. If the
nose continues to come in gray, then that is pathognomonic (absolutely
diagnostic) for "gray collie syndrome". Sable "gray collie syndrome" dogs
have brown or pale sable noses, but never black noses as they should
have.
DNA TEST
HealthGene Laboratory is the first DNA diagnostic laboratory that has
developed and offered a DNA-based test for Canine Cyclic Neutropenia.
HealthGene's test provides a reliable identification of dogs that carry
mutant gene(s). This test allows a breeder to control the mutant gene
frequency in the Collie breed thus preventing the production of puppies
affected with Canine Cyclic Neutropenia. This DNA test accurately and
specifically identifies normal, carriers (heterozygous) and affected dogs.
this test has been developed for the breeder so we can avoid this
disorder
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